The Sentences Book of James Essays - Sexual Fidelity, Adultery

The Sentences Book of James What I believe the writers are saying, when stating Love they neighbor is having respect for other people and having regard for his or her needs and desires as I have the same esteem for my personal wants and desires. James believes favoritism, not Gods characteristic, as we know the law of God is perfect, excellent and royal. What makes the law royal is because God is the author. We do not have to break all of the laws of God; if we break only law we have violated and disrespected God. As a Christian it is our duty and most importantly to keep Gods law. The laws of God are to be obeyed and followed. Obedience is vital to our Christian walk with Christ and our faith in God gives the ability to do what God says. When one commits adultery God holds that person accountable. If the adulterer breaks his or her promise they have become deceivers, liars and have lied to God. However, and adulterer can be forgiven of that sin, now as for the adulterers and homosexuals at the Church of Corinth (1 Corinthians 6:9-11). Therefore, these are considered serious consequence of human sin, and abominable crime of committing adultery. Jesus is our intercessor, in the New Testament Jesus says, Go and sin no more. These words of inspiration give the sinner a second chance and new beginning.

Martin Luther King Jr. Essay essays

Martin Luther King Jr. Essay essays Martin Luther King, Jr.'s birthday was first agknowledged as a national holiday in 1986. However, his life had become a part of Americans for years before this. To many African Americans whose rights he helped expand, to many other minorities whose lives his victories touched, and to many whites who welcomed the changes his leadership brought, Mr. King's life seemed overwhelming even as he lived it. He is celebrated as a hero not only for the eyes he's opened, but for his dreams and hopes he shared during a time of change. After long training in the North, Mr. King returned to his home, becoming a pastor of Dexter Avenue Baptist Church in Montgomery, Alabama. Mr. King became the leader of the Montgomery Bus Boycott when it broke out in 1955. That year long non-violent protest, which led to a Supreme Court ruling against bus segregation, brought Mr. King to the attention of the entire country. The occurances immediately following were less successful, but still provided Mr. King with the opportunity to strengthen his protest strategies. Then, in 1963, Mr. King and the SCLC (Southern Christian Leadership Conference) joined a campaign in Birmingham, Alabama to end segregation there and to force downtown businesses to allow blacks to work. Peaceful protests were not long after met by fire hoses and attack dogs, joined by local police. Images of this violence broadcast on national news, began an outrage, and this reaction stirred the political atmosphere, and the next year President Lyndon Johnson signed into law the Civil Rights Act of 1964. Meanwhile the SCLC was repeating the tactics of Birmingham in Selma, Alabama but this time for the African American voter registration. Once again, images of the police brutality because of the protest helped the passage of federal legislation, this time the Voting Rights Act of 1965. The community of black activists felt that these two major victories set the limit of what gains could still ...

Structureâ€Based Design and Synthesis of 2-Benzylidene-benzofuran-3-ones as Flavopiridol Mimics The WritePass Journal

Structure–Based Design and Synthesis of 2-Benzylidene-benzofuran-3-ones as Flavopiridol Mimics Conclusion Structure–Based Design and Synthesis of 2-Benzylidene-benzofuran-3-ones as Flavopiridol Mimics Introduction Experimental ProcedureResultsConclusionRelated Introduction Flavopiridol, a well-established inhibitor of cyclin-dependent kinases (CDK’s), is currently undergoing clinical trials. The inhibition of CDK’s, which are involved in the cell division cycle, is a vital goal in anticancer agents and therefore having potent drugs which can selectively inhibit these is crucial. One of the aims is to synthesize 2-benzylidene-benzofuran-3-ones so that they are more potent at inhibiting some of the CDK’s but also selective in nature, something which flavopiridol lacks. To date falvopiridol has been found to inhibit CDK’s 1, 2 and 4 all with the same potency. Flavopiridol acts on the CDK2 enzyme by mimicking the actions of the purine group of ATP. It is the keto and hydroxyl groups of the compound which form the same bidendate hydrogen bonds with the backbone of the CDK2 residues as the nitrogen atoms of the purine functional group of ATP. Having obtained this information it was clear to see that some variations of the benzafuranone structure would be able to mimic the interactions that flavopiridol has with CDK’s. The main objective of testing structural analogues was to obtain new CDK inhibitors that are more selective in discriminating between CDK2 and CDK4. Different substituents were attached to the phenyl ring, with modelling suggesting that a hydrogen bond acceptor group in para position would interact favourably whereas a bulky and positively charged para substituent would have a detrimental effect on CDK2 inhibition but not for CDK4. Experimental Procedure The derivatives of benzafuranone are synthesized in a set of continuous reactions starting with the acid-catalysed condensation of dimethoxy phenol and 1-methyl-4-piperidone in acetic acid. This produces an unsaturated derivative at 62% yield which is then followed by hydrogenation and treatment with chloroacetyl chloride and aluminium chloride to produce a derivative at 50% yield. The compound is then condensed with 4-bromobenzaldehyde to produce a derivative at 41% yield. Finally the aryl bromide derivative is reacted with 1-methylpiperazine and pyridinium hydrochloride to produce a benzofuranone with one R group being the methylpiperazine and the other being a hydrogen group at a 40% yield (8). The compound 8 and 4 others with different R groups were tested in kinase inhibition assays to see their effect on CDK’s 1, 2 and 4. Results The derivative with both R groups being hydrogen’s (4), proved to be as potent as flavopiridol at inhibiting CDK1 but not as effective against CDK2 and CDK4. The variation of potency of the derivative shows that there was a difference in the sensitivity between the enzymes. Moreover it proved that the synthesized benzofuranone derivatives whilst being potent maintained the high selectivity which was desired. When a chlorine atom was added at the ortho position on the phenyl ring the potency generally went down against all the CDK enzymes. The reason for this is that due to the presence of the chlorine there is some steric hinderence preventing the favourable conformation being adopted. Two other compounds which contain SO2NH2 and NO2 respectively as their R groups proved to be more potent than the first derivative in inhibiting CDK1 and CDK2. Both compounds contained hydrogen bond acceptor groups in their para positions and so this acted favourably in terms of conserving lysin e residue in the enzyme. The reason for a lower potency against CDK4 was due to the lack of conservation of lysine. The slight increase when a sulphonamide group was present as opposed to a nitro group is the result of its additional capacity to donate hydrogen bonds. Compound 8 was again more potent than the derivative with two hydrogen groups as the side chains. This was more prominent in the inhibition of CDK1 as there seemed to be a greater amount of repulsive interaction with the lysine at the 89th position. There wasn’t any noticeable difference in the potency between the compound 8 and 4 due to the ability of compound 8 being able to access the free solvent space due to the replacement of the lysine (at the 89th position) by a threonine. Conclusion The compounds obtained from the generalised structure of 2-benzylidene-4,6-dihydroxy-7-benzofuran-3-ones showed inhibitory characteristics which are true of flavopiridol mimetics. Through careful manipulation of the structure it was possible to increase the inhibitory potency against the CDK1 and CDK2 enzymes and obtain selectivity against CDK4 due to the lack of conservation of lysine. However it was often difficult to increase the inhibition at CDK4 due to shape of   the ATP binding site which prevented favourable interactions between the ligand occurring.

Major Components and Guidelines for Developing a Master Plan of Essay - 1

Major Components and Guidelines for Developing a Master Plan of Evaluation - Essay Example Mr. Smith; The significant groups of individuals involved are the government of the particular country, the chief executive officer of the institution, the head of curriculum development, student leader among others. It depends on the urgency of the situation; for instance, the CEO will be play the focal role in this process ; hence will be required to connect aptly with other parties especially the government. This is to ensure that the process is legal and follows the policies and rules set aside. The data finding will recorded and analyzed later in regards to the place and individual the data was collected from. In this field only variables data are experienced and ought to relate with one another. The most essential requirement prior to the development of any master plan of evaluation is the compliance to the pre-set rules and regulations governing the nursing sector. This is because these standards boost quality in service delivery and discipline. In addition, this compliance creates confidence of the stakeholders in the nursing fraternity because of the quality of service in nursing and the involvement of the international nursing bodies in the assessment of the compliance of the sector to the set standards. Nurses undergo programs tailored at offering proper training to have delivery of quality service. These programs include the master plan of evaluation in the training. The plan acquaints the nurses with the necessary information regarding the nursing career. For instance, it highlights the areas of the faculty that need evaluation. This includes methods to be employed in the evaluation. The type of people to participate in the process is anchored in the plan. The action plans required to give feedback on the various inferences made with regard to boosting the quality in nursing service delivery. In addition, the master plan evaluation helps in the

Social media critical analysis Essay Example | Topics and Well Written Essays - 750 words

Social media critical analysis - Essay Example There are several instances where differences arise in the way people perceive others, something that has resulted in ethnicity, racism and other perspectives that carry negative impacts and connotations. This paper examines the issue of racism and ethnic connotations that are continually becoming the main agenda across social media and other platforms in the society. It focuses on how these thoughts and perspectives are taking toll on the society and the perceived implications they are creating, as well as steps being taken to create a cross-cultural social platform. In our contemporary society, ethnicity is standing out as the cause of disagreements across human societies. Our society penalizes people that openly talk about racial issues; these gaps provide perfect grounds upon which honest conversations effecting their particular communities are raised (Miller 3), this statement continues to elicit mixed reactions across many platforms. Currently, marketers across the business world are realizing the need to make objective communications in order to attract clients that have different origins in terms of their ethnic affiliations, race and preferences. This is because; businesses create products that are destined to fulfill the needs of all people in the society irrespective of their differences. This has yielded efforts and strategies in creating a non-polarized media that appeals to all the needs of the different groups of people for all the good reasons. While marketers have been making efforts in dropping their long-held traditional ethnic media, they are scrambling to establish a platform that is cross-cultural, and lacking ethnic connotations. These efforts are expected to eliminate the hate and related outcomes that are often brought about by ethnic connotations and perspectives that people hold in the physical societies that we live in. Currently, people want to be associated with others of their own race, ethnicity,

Article Review Example | Topics and Well Written Essays - 500 words - 1

Review - Article Example However, not only were their actions racist, albeit disguised thinly, â€Å"[b]ut the new policies were also deeply embedded in widespread and widely shared assumptions† (Kessler-Harris 2010, 437) that can only be classified as sexist. Those busy in reforming the law made it clear that they were more interested in safeguarding what was, then, classic American way of life, than safeguarding the rights of all. The reforms that were proposed sought to take contributions from all working people, yet it did not give back the money as Social Security to all who had contributed. Families of men, and then too those belonging to certain occupations, were entitled to the money in case of the death of the man. However, what is interesting is that widows who remarried or who did not have young children and had not reached the age of 65 yet were excluded. Moreover, the social security of a widow â€Å"was to be reduced or eliminated if her earnings exceeded fifteen dollars a month† (Kessler-Harris 2010, 439). In order to win over the racists who were still present in Congress, the reformers also kept in hidden clauses that ensured that colored workers will not be entitled to the Social Security money. Fields of employment which were predominantly black, like agricultural workers, were excluded from the entitlement list. The reformers excluded household workers from the list of the entitled class of workers, and with 90% of the household working force being female and 45% of it being black (Kessler-Harris 2010), they not only excluded women, but caused the black women a double jeopardy of sorts, as most of the men in their family were already excluded based on the racist reforms. Of course, this clearly suggests that they thought a woman was to be subservient to a man and it was the duty of the man to provide and for a woman to take care of the home. Therefore, a widow who remarried or who had old children had someone else to look after her and so was not considered entitled.

Paraphrasing Essay Example | Topics and Well Written Essays - 750 words - 6

Paraphrasing - Essay Example This question actually merits a deeper introspection for it is complex and sophisticated. Linear reasoning methods seem to provide fewer clues when it comes to having a good answer. It is clear, however, that people who have gone to universities show varied results that require a closer and deeper scrutiny. This is especially true when comparing the experiences of men and women who achieved college degree and gained relative professional success only to fail when it came to creating meaningful personal relationship in the real world. If Newman is to be believed, universities are tasked with the role of creating men and women who will have a ‘philosophical habit’ that encourages ‘freedom, equitableness, calmness, moderation and wisdom’ (Newman, 1852, p.53). Many universities have succeeded in doing this to many of those admitted therein. As such, universities prepare young people to be ready to face and survive the real world, and can be observed that those who have university degree or college education are the ones who are the most timid and more docile people in the world. These people are law-abiding citizens, who know what to do and not to do in regards to following the law. These university graduates are people characterized as having education that taught them how to conform to the society. This definition of universities by Newman is applicable to both men and women; yet, some argue that women need different education systems. It must be remembered that Adrienne Rich (1979) stated that women educational needs are different from men. Also, Rich said in her 1979 speech â€Å"No women’s college today is providing young women with the education they need for survival as whole people in a world which denies woman wholeness† (p.74). This is based on the new school of thought separating and giving women identity from what many conceive based on